The Effect of Di-(2-Ethylhexyl) Phthalate (DEHP) on Mouse Daily Sperm Production and Epididymal Sperm Parameters

Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.

Di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) were mixed with diet at graded levels of 0.05, 0.1, 0.2. 0.4 and 1.0 wt-% and given to pregnant ICR mice throughout gestation. Maternal weight gain was suppressed and fetal resorption increased at 0.2, 0.4 and 1.0% levels of DEHP and 1.0% level of DBP. All the implanted ova died early in rats fed 0.4 and 1.0% levels of DEHP. Exter...

Toxicological Profile for Di-(2-ethylhexyl) Phthalate (dehp)

Long-term effects of maternal exposure to Di (2-ethylhexyl) Phthalate on sperm and testicular parameters in Wistar rats offspring

BACKGROUND Phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. OBJECTIVE This study was designed to assess long-term effects of maternal exposure to Di (2-ethylhexyl) Phthalate (DEHP) on reproductive ability of both neonatal and adult male offspring. MATERIALS AND METHODS 60 female rats randomly divided in four equal groups; vehicle control ...

Migration of di-(2-ethylhexyl)phthalate (DEHP) and diisononyl phthalate (DINP) from PVC articles

Zusammenfassung DEHP und DINP sind Primärweichmacher, die in vielen Weich-PVC-Artikeln wie Beißringen für Kleinkinder eingesetzt werden. Die Ultraschallbad-Extraktion scheint gut geeignet zur Bestimmung der Migration von Phthalaten aus Kunststoff-Gegenständen und liefert Werte, wie sie auch beim Saugen mit Testpersonen erhalten worden waren. Die höheren Migrationsraten, die beim Kauen der Kunst...

NTP Research Concept: Di(2-ethylhexyl) Phthalate (DEHP) and Phthalate Mixtures

program prior to designing and conducting toxicology studies. The purpose of the research concept document is to outline the general elements of a research program that would address the specific public health concerns that prompted the nomination of the substance or issue for study. It may also encompass substance-specific studies that address larger public health issues or topics in toxicolog...

long-term effects of maternal exposure to di (2-ethylhexyl) phthalate on sperm and testicular parameters in wistar rats offspring

background: phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. objective: this study was designed to assess long-term effects of maternal exposure to di (2-ethylhexyl) phthalate (dehp) on reproductive ability of both neonatal and adult male offspring. materials and methods: 60 female rats randomly divided in four equal groups; vehicle control a...